Results
| PMID | 8092224 |
| Gene Name | CSF2RB |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 27 |
| Population details | 27 (19 endometrial biopsy samples, 8 disease free patients) |
| Sex | Female |
| Associated genes | GM-CSF |
| Other associated phenotypes |
Endometriosis |
|
Am J Obstet Gynecol. 1994 Sep;171(3):740-5. Sharpe-Timms, K L| Bruno, P L| Penney, L L| Bickel, J T Department of Obstetrics and Gynecology, University of Missouri, Columbia 65212. OBJECTIVE: Murine endometrial granulocyte-macrophage colony-stimulating factor has been related to macrophage recruitment and activation and postulated to mediate reproductive events. This study was designed to determine whether granulocyte-macrophage colony-stimulating factor is present in normal human endometrium or endometriosis. STUDY DESIGN: Granulocyte-macrophage colony-stimulating factor was immunohistochemically evaluated in matched endometrial and endometriosis biopsy specimens (n = 19) and endometrial biopsy specimens from disease-free patients (n = 8). Staining differences were determined with McNemar's, Fisher's, and Wilcoxon's tests. RESULTS: Granulocyte-macrophage colony-stimulating factor was primarily localized in endometrial and endometriotic epithelial cells. Expression (p = 0.71) and staining intensity (p = 0.37) was similar in matched proliferative-phase endometrium and endometriosis. Matched secretory-phase endometrium and endometriosis also expressed granulocyte-macrophage colony-stimulating factor in similar proportions (p = 0.12), but staining intensity was enhanced in secretory endometriosis compared with secretory endometrium (p = 0.05). Endometrial granulocyte-macrophage colony-stimulating factor did not vary throughout the menstrual cycle, but endometriotic expression (p = 0.013) and staining intensity (p = 0.008) were significantly greater in the secretory phase. CONCLUSIONS: Granulocyte-macrophage colony-stimulating factor is localized in endometrial and endometriotic epithelial cells with increased expression in secretory-phase endometriosis. Granulocyte-macrophage colony-stimulating factor may elicit migration, proliferation, and activation of endometrial and peritoneal macrophages. Mesh Terms: Endometriosis/*metabolism| Endometrium/*metabolism| Epithelium/metabolism| Female| Granulocyte-Macrophage Colony-Stimulating Factor/*metabolism| Humans| Immunohistochemistry| Menstrual Cycle| Observer Variation|DA 1994/09/01 00:01 |
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